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04-9-1015-96/2008
Priority:1
Status: In-progress

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment

Leader:   E.A. Krasavin
G.N. Timoshenko

Scientific Programme:
Radiation risk assessment is a crucial problem in occupational and public protection. It is well known that there is a lack of data needed to estimate risk of radiation stochastic effects (mutations and cancer diseases). Therefore, there is a need for obtaining new fundamental data on the induction of radiation stochastic effects for radiation with different linear energy transfer (LET). Accelerators and reactors of the Joint Institute are an excellent tool for modern radiation and radiobiological researches and give a unique possibility to obtain such data. The ultimate goal is to obtain fundamental physical and biological data based on experimental research at basic facilities of JINR and on theoretical modeling of ionizing radiation interaction with matter. Accelerators and radiochemistry facilities of JINR are able to produce different radionuclides for development of new radiopharmaceutical preparations as well. Research and development will include:
- LET and neutron spectrometry, radiation and biosensor monitoring;
- Theoretical modeling of ionizing radiation interaction with matter including interactions with biological structures and shielding calculations;
- Experimental data obtained for verification of theoretical modeling of ionizing radiation interaction with matter;
- Investigations of peculiarities and mechanisms of point and structural mutation induction in pro- and eukaryotic cells by radiation with different LET;
- The problem of low doses of radiation with different LET and cell recovery;
- Genetic and radiation monitoring of environment nuclear installations with biosensors and radiation monitors;
- Investigation of "methylene blue - 211At" complex therapy efficiency in melanoma cells.

As the results:
- Methods for radiation and genetic monitoring at nuclear installations of JINR and in environment will be developed;
- Fundamental data for radiation risk assessments will be obtained;
- Methods for targeted radiotherapy and diagnostics of melonoma will be developed.

Expected main results in 2007:
List of Activities
  Activity or Experiment Leader
Status
1. Radiobiological research at heavy charged particle beams E.A. Krasavin
Data taking
Realization
R&D
2. Radiation research G.N. Timoshenko
Preparation
Data taking
R&D
3. Radiophotobiological research M.A. Ostrovsky
Preparation
Data taking
R&D
4. Computer molecular modeling Kh.T. Kholmurodov
Preparation
Data taking
R&D
5. Training activity V.E. Aleinikov
E.A. Krasavin
D.V. Fursaev
 

Collaboration
Country or international
organization
City Institute or Laboratory
Armenia Yerevan YerPhI
Belarus Minsk BSU
IRB NASB
Bulgaria Sofia IE BAS
INRNE BAS
NCRRP
Czech Republic Brno IBP ASCR
IRG ASCR
Rez NPI ASCR
NRI
Germany Darmstadt GSI
JINR Dubna VBLHE
DLNP
FLNR
LPP
LIT
UC
Poland Warsaw INChT
Cracow NINP PAS
Otwock-Swierk IAE
Romania Bucharest U.M.F."Carol Davila"
Russia Moscow IBMP RAS
MMA
MSU
RCRC RAMS
Gatchina PNPI RAS
Protvino IHEP
Puschino ITEB RAS
Slovak Republic Bratislava CU
IPCM
SIM
Kosice IAP SAS
Ukraine Kiev ICBGE NASU
Sevastopol IBSS NASU
Vietnam Hanoi IPE VAST

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