THEME04-9-1015-96/2008

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04-9-1015-96/2008

Priority:

Status:

Approved for completion
in 2008

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment

Leaders:

E.A. Krasavin
G.N. Timoshenko

Scientific Programme:
Radiation risk assessment is a crucial problem in occupational and public protection. It is well known that there is a lack of data needed to estimate risk of radiation stochastic effects (mutations and cancer diseases). Therefore, there is a need for obtaining new fundamental data on the induction of radiation stochastic effects for radiation with different linear energy transfer (LET). Accelerators and reactors of the Joint Institute are an excellent tool for modern radiation and radiobiological researches and give a unique possibility to obtain such data. The ultimate goal is to obtain fundamental physical and biological data based on experimental research at basic facilities of JINR and on theoretical modeling of ionizing radiation interaction with matter. Accelerators and radiochemistry facilities of JINR are able to produce different radionuclides for development of new radiopharmaceutical preparations as well. Research and development will include:
- LET and neutron spectrometry, radiation and biosensor monitoring;
- Theoretical modeling of ionizing radiation interaction with matter including interactions with biological structures and shielding calculations;
- Experimental data obtained for verification of theoretical modeling of ionizing radiation interaction with matter;
- Investigations of peculiarities and mechanisms of point and structural mutation induction in pro- and eukaryotic cells by radiation with different LET;
- The problem of low doses of radiation with different LET and cell recovery;
- Genetic and radiation monitoring of environment nuclear installations with biosensors and radiation monitors;
- Investigation of "methylene blue - ²¹¹At" complex therapy efficiency in melanoma cells;
- Investigations of cataractogenic mechanisms of ionizing radiation with different LET;
- Computer molecular simulation of complex biological structures;
- Study of ultra high frequency electromagnetic radiation on heavy metal nanoclustrers incorporated into biological structures;

As the results:
- Methods for radiation and genetic monitoring at nuclear installations of JINR and in environment will be developed;
- Fundamental data for radiation risk assessments will be obtained;
- Methods for targeted radiotherapy and diagnostics of melonoma will be developed.

Expected main results in 2008:

Data on structural damages of chromosomal system at small dose radiation with different LET.
Data on human DNA molecular injury at action of heavy charged particles.
Data on mechanism of cataractogenesis and eye structure damage due to action of heavy charged particles.
Development of methods for recognition of hidden damages in biological membranes irradiated by heavy charged particles.
Radiobiological experiments at LHE nuclotron and LNR cyclotron.
MD simulation of the main biomolecular structures.
Radiation shields estimation for the projects of new accelerators.
Data on influence of ultra high frequency electromagnetic radiation on heavy metal nanoclustrers incorporated into biological structures.

List of Activities

Activity or Experiment

Leader

Status

Radiobiological research at heavy charged particle beams

E.A. Krasavin

Data taking
Realization
R&D

Radiation research

G.N. Timoshenko
V.M. Petrov

Preparation
Data taking
R&D

Photoradiobiological research

M.A. Ostrovsky

Computer molecular modeling

Kh.T. Kholmurodov

Training activity

V.E. Aleinikov
E.A. Krasavin
D.V. Fursaev

Collaboration
Country or international organization	City	Institute or Laboratory
Armenia	Yerevan	YerPhI
Belarus	Minsk	BSU
		IRB NASB
Bulgaria	Sofia	IE BAS
		INRNE BAS
		NCRRP
Czech Republic	Brno	IBP ASCR
	Rez	NPI ASCR
		NRI
Germany	Darmstadt	GSI
Poland	Warsaw	INChT
	Cracow	NINP PAS
	Otwock-Swierk	IAE
Romania	Bucharest	U.M.F."Carol Davila"
Russia	Moscow	IBMP RAS
		MMA
		MSU
		RCRC RAMS
	Gatchina	PNPI RAS
	Protvino	IHEP
	Puschino	ITEB RAS
Slovak Republic	Bratislava	CU
		IPCM
		SIM
	Kosice	IAP SAS
Ukraine	Kiev	ICBGE NASU
	Sevastopol	IBSS NASU
Vietnam	Hanoi	IPE VAST

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Radiation and Radiobiological Investigations at the JINR Basic Facilities and in the Environment

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment