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Research of Biological Action of Heavy Charged Particles
with Different Energy

• Study of DNA damages in human cells induced by heavy charged particles;
  
  
• Study of kinetic repair after irradiation by gamma and heavy ions;
  
  
• Investigation of peculiarities and mechanisms of stable and unstable chromosome aberrations induction in human cells, point and structural mutation induction in low eukaryotic cells by irradiation with heavy charged particles;
  
  
• Study of chromosomal aberrations induced by radiation with different LET in low doses;
  
  
• Study of the damaging effect of heavy charged particles in retina and crystalline lens in mammalian eyes;
  
  
• Computer molecular modeling and simulation analysis of biological structures;
  
  
• Estimation of biological efficiency of therapeutic proton and carbon beams on the human cells through cytogenetic consequences of peripheral blood lymphocytes;
  
  
• Theoretical modeling of ionizing radiation interaction with matter (including interactions with biological structures), shielding and activation calculations;
  
  
• Prognostication of radiation situation at new nuclear facilities, large experimental installations and spacecraft boards;
  
  
• Investigation in the field of "targeted cancer therapy".

• New data on biological effectiveness of accelerated heavy ions on the cells with different genetic organization;
  
  
• Development methods for recognition and quantitative analysis of hidden damages in biological membranes;
  
  
• Developed mathematic simulation of mutagenesis in E.coli cells induced by UV irradiation;
  
  
• New data on cataract induction in mice by heavy charged particles;
  
  
• Molecular dynamic simulation of radiation induced damages and mutations in biological structures;
  
  
• Improved methods for calculation of radiation transport through matter and for calculation of radiation induced damages in biological structures;
  
  
• New data on influence of SHF electromagnetic waves on gold nanoclusters incorporated in cancer human cells;
  
  
• Calculation of radiation shields of new accelerators and large nuclear facilities at JINR and its Member States.

• Data on induction of double strand breaks of DNA in human blood lymphocytes at action of heavy charged particles.
  
  
• Data on regularities of unstable chromosome aberrations in human lymphocytes after irradiation in low doses.
  
  
• Data on regularities of cataract induction in mice by irradiation with 100-200 MeV.
  
  
• Modeling of SOS-repair processes in E.coli cells involved in mutagenesis induced by UV irradiation.
  
  
• Dosimetric and physical support of radiobiological experiments at the VBLHEP Nuclotron, FLNR cyclotron U400M and at the medical beam of the DLNP Phasotron.
  
  
• MD simulation of the important biomolecular structures.
  
  
• Radiation shields estimation for the projects of new accelerators.
  
  
• Data on influence of SHF electromagnetic radiation on gold nanoclusters incorporated into biological structures.
  
  

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