Next theme	Prev. theme
to field of reseach	to contents

Research on the Biological Action of Heavy Charged Particles
with Different Energy

• Acquisition of new data on molecular disorders in human cell DNA under heavy charged particles and on structure lesions in the chromosome apparatus under low doses of radiation with different linear energy transfer;
  
  
• Decoding mechanisms determining cell hypersensitivity and hyperresistance to low doses of ionizing radiation;
  
  
• Acquisition of new data on the genetic control of the induced mutation process in cells with different levels of the genome organization;
  
  
• Development of methods of identifying hidden lesions in biological membranes induced by heavy charged particles;
  
  
• Comparative evaluation of the influence of therapeutic proton and carbon beams on human cells based on cytogenetic disorders in peripheral blood lymphocytes;
  
  
• Drawing up recommendations on the threshold doses of ionizing radiation able to cause damage in the crystalline lens and retina. Working out measures of cataract prevention among staff occupationally exposed to ionizing radiation;
  
  
• Molecular dynamics simulation of radiation-induced damage and mutations in biological structures;
  
  
• Calculation of radiation protection measures for new nuclear physics facilities, evaluation of their radiation situation, and development of radiation safety systems for them;
  
  
• Estimation of galactic cosmic radiation doses for cosmonauts in different flight scenarios for working out the criteria and grounds of radiation safety standards for interplanetary flights;
  
  
• Development of new approaches for tumor-targeted therapy.
  

• New data on the biological effect of accelerated heavy ions on the cells with different genetic organization;
  
  
• Development of methods for recognition and quantitative analysis of hidden damages in biological membranes;
  
  
• Development of mathematical simulation of mutagenesis in E.coli cells induced by UV irradiation;
  
  
• New data on cataract induction in mice by heavy charged particles;
  
  
• Molecular dynamic simulation of radiation induced damages and mutations in biological structures;
  
  
• Improved methods for calculation of radiation transport through matter and for calculation of radiation-induced damages in biological structures;
  
  
• New data on the influence of SHF electromagnetic waves on gold nanoclusters incorporated in human cancer cells;
  
  
• Calculation of radiation shielding of new accelerators and large nuclear facilities at JINR and its Member States.

• Continuation of studying regularities in the induction of different types of DNA lesions, apoptosis, and repair in human lymphocytes in different phases of the cell cycle under ionizing radiation with different physical properties in the presence of modifiers.
  
  
• Study of the combined effect of gamma radiation and lipid A obtained from Escherichia coli on phagocytosis, lysozyme, and peroxidase activities of human peripheral blood lymphocytes.
  
  
• Acquisition of data on the influence of a disorder in the mitochondrial genome on the lethal and mutagenic effects of ionizing and non-ionizing radiation.
  
  
• Acquisition of data on the role of the active forms of oxygen and intracellular signal systems in the formation of the dose dependence of the chromosome aberration induction in mammalian and human cells by low doses of radiation.
  
  
• Acquisition of data on the mechanism of cataract induction in mice by 100–200-MeV protons.
  
  
• Mathematical modeling of the mutagenic effect of ionizing radiation with different linear energy transfer on bacterial cells.
  
  
• Dosimetric and physical support of radiobiological experiments at the VBLHEP Nuclotron, FLNR cyclotron U400M and the medical beam of the DLNP Phasotron.
  
  
• Molecular dynamics simulation of structures of biologically important macromolecules.
  
  
• Prediction of the radiation situation at JINR's new nuclear physics facilities and aboard spacecraft.
  
  

Next theme	Prev. theme
to field of reseach	to contents