THEME02-1-1107-2011/2013

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02-1-1107-2011/2013

Priority:

Status:

In-progress

Development and Construction of the Prototype of a Complex for Radiotherapy and Applied Research with Heavy-Ion Beams at the Nuclotron-M

Leaders:

S.I. Tyutyunnikov
J. Ruzicka
M.G. Kadykov

Participating Countries, Institutes and International organizations:
Armenia, Australia, Belarus, Bulgaria, Czech Republic, India, Germany, Greece, Kazakhstan, Moldova, Mongolia, Poland, Romania, Russia, Serbia, Slovak Republic, Ukraine.
Scientific Programme:
The main goal of the theme is construction a Medical-biological complex based on the VBLHEP accelerator of protons and ions and carrying out a research programme in the field of medical biology and oncology therapy. On the first stage it is planned to develop new equipment for ion beam shaping and monitoring. Research programme in the field of influence of nanostructual complexes of heavy metals on radiating damages of biological cells, research of local destruction of cancer cells by/upon microwave/super frequency heating of metal nanoclusters. Investigation of some new aspects of radioactive waste transmutation and nuclear energy production. Investigation of thermal and hydrodynamics regimes for nuclear facilities.

Expected main results:

Development of a transportation channel for carbon ions with energy E=200-250 MeV/n. with a beam size of 2-3 mm produced by the Nuclotron and by the booster of the NICA complex. Calculations and construction of the fast scanning system of this beam in XY-directions, manufacture and adjustment of the diagnostic equipment for the control of energy and spatial characteristics of carbon beam. The ultimate goal is carrying out of phantom irradiations aimed to define the necessary dose characteristics for the therapy of cancer tumors.
Investigation of the physical characteristics of the assemblies: "a lead target plus grafit moderator" (set-up the "Gamma-3"), a massive uranium target with a lead reflector - (set-up "Quinta"), a quasi infinite uranium target at energies of proton and deuteron beams in the interval from 0.6 up to 12.0 GeV from the Nuclotron. Data on the multiplicities and special distribution of energy-time spectra of neutrons. Investigation of possibilities of energy production and processing of radioactive waste on massive target of natural (depleted) uranium and thorium based on the basic principles of nuclear technology.
Construction of superconducting elements for monitoring systems.

Expected main results in 2012:

Calculations of scanning and focusing systems of the carbon ion beam.
Engineering of the system for spatial monitoring of the carbon beam on the target in real time mode, construction of the model of this system and its test on the Nuclotron-M beam.
Development and manufacturing of detector prototypes for measurement of carbon ion energy in the range E=100-250 MeV/n.
Development of a technical project for the channel output beam of carbon nuclei of the NICA Booster in the experimental zone for a prototype installation for radiocarbon therapy.
Development of cryogenic metrological complex in VBLHEP:

- Maintaining of cryogenic metrological complex in working condition;

- Development of an innovative two-phase flow void fraction meter of helium;

- Development of hardware and software to measure two-phase flows of helium.
Study on the model structures of the efficiency of heating by microwave radiation FEL ferromagnetic nano-clusters of cobalt with a view to their possible use to destroy cancer cells.
Study of generation and multiplication of neutrons in heavy targets (Pb and U) under irradiation by proton and deutron beams of the Nuclotron within the energy interval (0.6-12.0) GeV. Data taking on neutron energy spectra and their spatial distribution and radioactive waste transmutation rates in uranium and lead targets with uranium blanket (set-up "Quinta") and in a lead target witn graphite moderator ("Gamma-3" set-up). Study of transmutation characteristics of highly toxic long-lived radioactive waste products (¹²⁹I, ²³⁷Np, ²³⁸Pu, ²³⁹Pu and ²⁴¹Am) in neutron field of above mentioned targets.
Study of structual material properties in neutron fields.

List of projects:
	Project	Leader	Priority (period of realisation)
1.	Development of prototype units for a Complex of Carbon Radiotherapy	S.I. Tyutyunnikov	1 (2010-2012)
2.	Study of deep subcritical electro-nuclear systems and feasibility of their application for energy production and radioactive waste transmutation	S.I. Tyutyunnikov	1 (2011-2013)

List of Activities

Activity or Experiment

Leader

Status

Laboratory and
Responsible person

Main researchers for the Laboratory

Carrrying out of calculations of beam dynamics and design of ion-optical system for transportation and focusing of carbon ion beam

I.P. Yudin

Realization

VBLHEP

V.S. Alexandrov, V.A. Panasik, E.E. Perepelkin

Research and development of the system prototype for 2D scanning of carbon ion beam

A.A. Fateev
N.I. Lebedev

Realization

Development and manufacturing of two-dimensional detector, system for spatial monitoring of carbon ion beam in real time mode and creation of beam control systems in the scanning mode. Development of prototype for automated three-dimensional scanning beam

V.A. Vishnevsky
N.I. Zamyatin

Realization

VBLHEP

A.V. Pilyar, A.V. Tcheryemukhin, S.V. Khabarov

Research of efficiency of biological cell destruction in metal nanoclusters of various structure by microwave heating. Study of its properties in dependence on duration and power of radiation spectrum

S.I. Tyutyunnikov
S.N. Sedykh
E.A. Perelshtein
V.N. Shalyapin

Realization

VBLHEP

A.K. Kaminsky, I.A. Kryachko, G.M. Arzumanyan, V.V. Efimov, Yu.S. Kovalev, V. Dzhavadova

Preparation of the project of the medical-biological complex on the basis of the Booster of the NICA project

S.I. Tyutyunnikov
J. Ruzicka
I.P. Yudin

Realization

VBLHEP

V.A. Mikhaylov, I.P. Yudin, V.A. Panasik

Study of neutron generation and transmutation rates in heavy targets under proton and deuteron irradiation with the beam energy up to 6 GeV. Study of structual changes of materials in the neutron fields

M.G. Kadykov
V.S. Pronskikh

Data taking
Data processing
Upgrade

VBLHEP

V.A. Krasnov, N.M. Vladimirova, E.V. Kostyukhov, I.I. Marin, A.F. Elishev, I.V. Kudashkin

DLNP

J. Adam, V.M. Tsupko-Sitnikov, A.A. Solnyshkin, V.I. Stegaylov

LRB

V.Yu. Shchegolev, G.V. Maslennikov

FLNP

N.A. Gundorin, Yu.N. Kopatch, V.I. Furman

LIT

A. Polansky

RFMD

B.A. Shestakov, N.N. Kalyakin + 2 pers.

Construction of elements for monitoring of superconducting systems

Yu.P. Filippov

Realization

VBLHEP

K.S. Panferov, I.D. Kakorin + 6 pers.

Collaboration
Country or International Organization	City	Institute or Laboratory
Armenia	Yerevan	YSU
Australia	Sydney	Univ.
Belarus	Minsk	JIPNR-Sosny NASB
	Minsk	IP NASB
Bulgaria	Sofia	INRNE BAS
Czech Republic	Rez	NRI
Germany	Darmstadt	TU Darmstadt
	Marburg	Univ.
	Julich	FZJ
Greece	Thessaloniki	AUTH
India	Mumbai	BARC
	Jaipur	Univ.
Kazakhstan	Almaty	IPT
		INP NNC RK
Moldova	Chi sina	IAP ASM
Mongolia	Ulaanbaatar	IPT MAS
Poland	Warsaw	WUT
	Krakow	NINP PAS
	Otwock-Swierk	NCNR
Russia	Obninsk	MRRC RAMS
		IPPE
	Dubna	BSINP MSU
		IAS "Omega"
	Tomsk	TPU
Romania	Bucharest	ISS
		UMF "Carol Davila"
		INCDIE ICPE-CA
Serbia	Belgrade	INS "VINCA"
Slovak Republic	Bratislava	SOSMT
		CU
Ukraine	Kharkov	KFTI NASU
	Uzhgorod	UNU

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