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Research on the Biological Effect of Heavy Charged Particles
with Different Energies

• Research on the effect of accelerated heavy ions of different energies on genetic structures.
  
  
• Research on the interaction between the main cataractogenic factors (ionizing radiation, ultraviolet radiation, and age) during lens opacity formation.
  
  
• Research on the effect of different doses of accelerated charged particles on the retina and central nervous system of experimental animals.
  
  
• Mathematical modeling of induced mutagenesis in bacterial and eukaryotic cells.
  
  
• Molecular dynamics modeling of spatial structures of complex protein aggregates participating in DNA repair in bacterial and higher eukaryotic cells.
  
  
• Working out radiation protection measures for new nuclear physics facilities, evaluation of their radiation environment, and development of radiation safety systems for them.

• Acquisition of new data on the regularities and mechanisms of the initiation of molecular disorders of the DNA structure; DNA damage repair; and radiation-induced apoptosis in human cells under radiations with different linear energy transfer (LET).
  
  
• Decoding of the mechanisms underlying cell hypersensitivity and hyperresistance to low doses of ionizing radiation.
  
  
• Acquisition of comparative data on the regularities of the induction of gene and structural mutations in yeast cells by radiations with different LET.
  
  
• Drawing up recommendations on the threshold doses of heavy charged particles able to damage the eye lens and retina. Development of the preventive measures against cataract in persons occupationally exposed to irradiation with heavy charged particles.
  
  
• Research on the character of the heavy charged particle-induced damage of the central nervous system (CNS) cells and regularities of their death. Identification of the heavy charged particle-induced functional disorders in the CNS.
  
  
• Molecular dynamics modeling of radiation-induced conformational changes in biological structures.
  
  
• Mathematical modeling of the mutagenic effect of ionizing radiations with different LET on bacterial and mammalian cells.
  
  
• Calculation of the radiation shielding of new accelerators and large nuclear facilities for JINR and its Member States.
  
  
• Estimation of the galactic radiation dose received by cosmonauts for different flight scenarios to work out the criteria and grounds of the radiation safety standards for interplanetary flights.
  
  
• Acquisition of new data on the performances of nanotechnology-based thermoluminescent detectors.

• Continuation of studying the regularities of DNA damage and repair in human lymphocytes in the presence of modifiers of reparative and replicative synthesis of DNA.
  
  
• Studying the kinetics of the expression of the proteins participating in radiation-induced apoptosis and DNA damage repair.
  
  
• Evaluating the contribution of non-homologous recombination to the DNA double-strand break repair.
  
  
• Acquisition of data on the regularities of the induction of structural mutations in yeast cells by radiations with different LET.
  
  
• Studying the mechanisms of the effect of low doses of radiations with different LET using modifiers of intracellular cytoprotective systems.
  
  
• Acquisition of data on the induction of cataract in mice by accelerated heavy ions.
  
  
• Continuation of the development of mathematical models of repair systems in bacterial and mammalian cells.
  
  
• Continuation of the development of models of the genetic control of the molecular mechanisms in bacterial and mammalian cells under ionizing radiations with different LET.
  
  
• Physical and dosimetric support of the radiobiological experiments at the Nuclotron (the Laboratory of High Energy Physics), U-400M (the Laboratory of Nuclear Reactions), and the medical beam of the Phasotron (the Laboratory of Nuclear Problems).
  
  
• Molecular dynamics modeling of the structural properties of the P53 protein.
  
  
• Prediction of the radiation conditions for the NICA project.
  
  
• Experimental studies of the performances of nanotechnology-based thermoluminescent detectors at heavy charged particle beams.
  
  

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