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Research on the Biological Effect of Heavy Charged Particles
with Different Energies

• Research on the effect of accelerated heavy ions of different energies on genetic structures.
  
  
• Research on the interaction between the main cataractogenic factors (ionizing radiation, ultraviolet radiation, and age) during lens opacity formation.
  
  
• Research on the effect of different doses of accelerated charged particles on the retina and central nervous system of experimental animals.
  
  
• Mathematical modeling of induced mutagenesis in bacterial and eukaryotic cells.
  
  
• Molecular dynamics modeling of spatial structures of complex protein aggregates participating in DNA repair in bacterial and higher eukaryotic cells.
  
  
• Working out radiation protection measures for new nuclear physics facilities, evaluation of their radiation environment, and development of radiation safety systems for them.

• Acquisition of new data on the regularities and mechanisms of the initiation of molecular disorders in the DNA structure; DNA damage repair; and radiation-induced apoptosis in human cells under radiations with different linear energy transfer (LET).
  
  
• Decoding of the mechanisms underlying cell hypersensitivity and hyperresistance to low doses of ionizing radiation.
  
  
• Acquisition of comparative data on the regularities of the induction of gene and structural mutations in mammalian and yeast cells by radiations with different LET.
  
  
• Drawing up recommendations on the threshold doses of heavy charged particles able to damage the eye lens and retina. Development of the preventive measures against cataract in persons occupationally exposed to irradiation with heavy charged particles.
  
  
• Research on the character of the heavy charged particle-induced damage of central nervous system (CNS) cells and regularities of their death. Identification of the heavy charged particle-induced functional disorders in the CNS.
  
  
• Molecular dynamics modeling of radiation-induced conformational changes in biological structures.
  
  
• Mathematical modeling of the mutagenic effect of ionizing radiations with different LET on bacterial and mammalian cells.
  
  
• Calculation of the radiation shielding of new nuclear physics facilities; evaluation of the radiation environment and development of radiation safety systems.
  
  
• Estimation of the galactic radiation dose received by cosmonauts in different flight scenarios for working out the criteria and grounds of the radiation safety standards for interplanetary flights.
  
  
• Acquisition of new data on the performances of nanotechnology-based thermoluminescent detectors.

• Continuation of research on the regularities of DNA damage induction and repair in human and mammalian cells in the presence of modifiers of DNA replication and repair synthesis.
  
  
• Continuation of research on the mechanisms of radiation-induced apoptosis and different ways of DNA damage repair under ionizing radiations of different qualities.
  
  
• Continuation of research on the regularities of the formation and repair of DNA double-strand breaks and clustered damage using the method of DNA foci.
  
  
• Continuation of research on the induction of gene and structural mutations in yeast cells by ionizing radiations of different LET.
  
  
• Completion of the experiments on the induction of gene and structural mutations in yeast cells by ultraviolet and gamma radiation.
  
  
• Performing a comparative analysis of the induction of the HPRT gene structural mutations and morphological changes in mutant subclones of mammalian cells by radiations of different LET.
  
  
• Continuation of research on the mechanisms of the action of low doses of radiations of different LET with the use of modifiers of the intracellular cytoprotective systems.
  
  
• Continuation of the acquisition of data on the regularities in the functional disorders in the rodent retina induced by radiations of different qualities and mutagens.
  
  
• Carrying out a study of the structural characteristics of the photoreceptor membrane containing the visual pigment rhodopsin – the receptor associated with the G-proteins.
  
  
• Development of a model approach to the description of the functional disorders in the rodent retina induced by ionizing radiations and mutagenes.
  
  
• Performing a research on the specifics of the biological effect of protons of different energies on the mouse organism.
  
  
• Carrying out an evaluation of the exposure of the central nervous system to the galactic and solar cosmic rays during a two-year interplanetary flight performed in different periods of the solar cycle.
  
  
• Continuation of the development of mathematical models of the functional activity of neurons under exposure to radiations of different LET.
  
  
• Development of a conceptual model of the diminution of an operator's functioning reliability associated with disorders in higher nervous activity.
  
  
• Continuation of the development of mathematical models of DNA double-strand break induction and repair in human cells.
  
  
• Conduction of radiobiological experiments at the Nuclotron (LHEP), U-400M (FLNR), and the medical beam of the Phasotron (DLNP).
  
  
• Carrying out the molecular dynamics modeling of the structural and functional properties of the DNA photolyase protein, G-proteins, and the protein rhodopsin surrounded by amino acid residues.
  
  

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