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Status: New

Modern Trends and Developments in Raman Microspectroscopy and Photoluminescence for Condensed Matter Studies

Leaders:     G.M. Arzumanyan
N. Kucerka

Participating Countries and International Organizations:
Armenia, Belarus, Bulgaria, Germany, Latvia, Poland, Russia, Slovakia, Ukraine, United Kingdom.

Scientific Programme:
Modern trends in Raman-based microspectroscopy providing ultrasensitive, highly-contrast and selective tools for condensed matter studies of extremely low concentrations of analyte molecules are in the focus of the present research programme. Detection and identification of a single molecule represent the ultimate sensitivity limit in chemical analysis. Tracking and counting of single molecules, characterizing their chemical structures, and monitoring of their structural changes offer far-reaching opportunities in basic and applied research. Therefore, vibrational spectroscopy, such as Raman spectroscopy, as a non-invasive, label-free technique, i_4es a powerful and preferred tool for single biological molecule studies. To achieve this goal, two enhanced options of Raman scattering, namely CARS (coherent antiStokes Raman spectroscopy) and SERS (surface-enhanced Raman spectroscopy) will be combined to attain such an ultrasensitive level of detection poorly studied and known as SECARS surface-enhanced CARS.

The other modern component of the theme is the study of photo- and upconversion luminescence based on promising core-shell nanostructures. In recent years, core-shell nanoparticles are at the leading edge of hot research topics and offer a wide range of applications in biomedicine, optics, environmental science, materials, and so forth, due to their excellent properties such as versatility, tunability and stability. The core?shell nanomaterials containing noble metals are plasmonic core?shell nanomaterials. They can be employed for contrast imaging, several biomedical applications, etc.}

Expected main results in 2018:
  • Upgrade of the "CARS" microspectrometer software "NanoSP" under the ultrasensitive modality SECARS.

  • Tests of various configurations of SERS-active substrates to ensure an optimal selection for the effective SECARS spectroscopy.

  • Obtaining and analysis of SERS and SECARS spectra and intensity maps of light scattered from organic reporter molecules attached to gold/silver nanoparticle.

  • Data on structural and spectroscopic/luminescent properties of core-shell nanostructure: NaYF4:Yb 3+, Er 3+,Tm 3+@SiO2.

  • Revealing of features of Raman spectra from C6 glioma cells and mesenchymal stem cells in regular studies.

List of projects:
  Project Leader Priority
(period of realisation)
Ultrasensitive SECARS
and luminescent core-shell
G.M. Arzumanyan
N. Kucerka
K.Z. Mamatkulov
1   (2018-2020)
List of Activities
  Activity or Experiment Leaders
  Laboratory or other
Division of JINR
Main researchers
1. Development of scientific and technical requirements for the upgrade of the "CARS" microspectrometer under ultrasensitive SECARS modality G.M. Arzumanyan
  FLNP K.Z. Mamatkulov, N.V. Doroshkevich, I.A. Morkovnikov
2. Study of spectroscopic and
plasmonic characteristics of
SERS-active substrates
based on silver/gold nanoparticles with different configurations
G.M. Arzumanyan
N. Kucerka
Data taking
  FLNP K.Z. Mamatkulov, N.V. Doroshkevich, E.A. Kuznetsov, K.O. Demeshenkova, V.N. Shatilova
3. Systematic experiments on SECARS microspectroscopy with picosecond laser pulses at SERS-active substrates single molecule spectroscopy G.M. Arzumanyan
K.Z. Mamatkulov
Data taking
  FLNP N.V. Doroshkevich, K.Sh. Voskanyan, K.O. Demeshenkova, V.N. Shatilova, I.A. Morkovnikov
4. Development of plasmon-enhanced
model of Raman scattering on the
"CARS" micposcope
G.M. Arzumanyan
N. Kucerka
  FLNP K.Z. Mamatkulov, I.A. Morkovnikov
5. Study of spectral-structural
characteristics of upconversion
phosphors based on core-shell
type nanostructures
G.M. Arzumanyan
N. Kucerka
Data taking
  FLNP K.Z. Mamatkulov, E.A. Kuznetsov, N.V. Doroshkevich, K.Sh. Voskanyan, K.O. Demeshenkova, V.N. Shatilova
6. Test-application of core-shell
nanostructured phosphors in
photodynamic therapy (PDT)
of cancer
G.M. Arzumanyan
N. Kucerka
  FLNP K.Z. Mamatkulov, E.A. Kuznetsov, N.V. Doroshkevich, K.Sh. Voskanyan, K.O. Demeshenkova, V.N. Shatilova
7. Verification of tumor and stem
cells by Raman microspectroscopy
G.M. Arzumanyan
N. Kucerka
Data taking
  FLNP K.Z. Mamatkulov, N.V. Doroshkevich, K.Sh. Voskanyan, I.A. Morkovnikov, K.O. Demeshenkova, V.N. Shatilova
8. Development of a united optical
platform concept for contrast and
selective imaging by nonlinear
Raman microscopy and
upconversion luminescence.
G.M. Arzumanyan
  FLNP K.Z. Mamatkulov, E.A. Kuznetsov
9. Expansion of research activities
at the "CARS" microscope
as a "user-friendly facility"
G.M. Arzumanyan
N. Kucerka
  FLNP K.Z. Mamatkulov, N.V. Doroshkevich

Country or International
City Institute or Laboratory
Armenia Yerevan Inst. Biochemistry NAS RA
Belarus Minsk BSUIR
Inst. Physiology NASB
SOL instruments
Bulgaria Sofia Inst. Microbiology BAS
Germany Julich FZJ
Latvia Riga ISSP UL
Poland Wroclaw UW
Poznan AMU
Russia Moscow GPI RAS
Slovakia Kosice PJSU
Ukraine Donetsk DonNU
United Kingdom Buckingham UB

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