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Biomedical and Radiation-Genetic Studies Using Different Types
of Ionizing Radiation
of Ionizing Radiation
| Leader: | G.V. Mitsyn |
| Deputy: | S.V. Shvidky |
Participating countries and international organizations:
Moldova, Czech Republic, India, Poland, Romania, Russia, South Africa
Issues addressed and main goals of research:
Mdico-biological and clinical research for the proton radiotherapy of cancer patients. Formation of an experimental data base in the field of radiation mutagenesis in the animal germ cells.
Expected results in the current year:
- Continuation of clinical researches on proton therapy
of cancer patients in Room 1. Evaluation of the effectiveness of the
conducted radiation treatment of different neoplasms.
- Work to increase the functional capability of the developed 3D treatment
planning software and its clinical tests in the treatment sessions.
- Design and construction of the prototype equipment for the dynamic conformal
irradiation of deep-seated tumours with the proton beam.
- Development and improvement of detectors and tools
for the clinical dosimetry of the medical hadron beams.
- Continuation of research to determine forms of fibroblast cell death depending on the dose of ionizing radiation.
- Study of mechanisms of functional and neurochemical disorders in the central nervous system under the action of radiation with different linear
energy transfer.
- Mastering of new methodes for evaluation of the effectiveness of the cytotoxic action of nanoparticles on tumour cells.
- Continuation of the molecular analysis of gamma- and neutron-induced intragenic structural changes in germline cells.
- Start of the sequence analysis of inherited DAN changes at the genome level of the offspring.
- Beginning of the work on the analysis of the transcriptome in somatic cells differing in radiosensitivity.
| List of projects: | |||
| Project | Leader |
Priority (period of realisation) |
|
| 1. | Further development of methods, technologies, schedule modes and delivery of radiotherapy |
G.V. Mitsyn K.Sh. Voskanyan |
1 (2017-2022) |
| 2. | RADIOGENE: Molecular genetics of radiation-induced changes at the gene, genome and transcriptome level in Drosophila melanogaster |
I.D. Alexandrov | 1 (2017-2022) |
| List of Activities | |||||
| Activity or Experiment | Leaders | ||||
| Laboratory or other Division of JINR | Main researchers | ||||
| 1. | Further development of methods, technologies, schedule modes and delivery of radiotherapy | G.V. Mitsyn K.Sh. Voskanyan |
| ||
| DLNP | A.V. Agapov, O.V. Belov, I.V. Alexandrova, K. Belokopytova,
| ||||
| 2. | RADIOGENE: Molecular genetics of radiation-induced changes at the gene, genome and transcriptome level in Drosophila melanogaster | I.D. Alexandrov |
| ||
| DLNP | M.V. Alexandrova, K.P. Afanasyeva, A.E. Ivanova, N.E. Kharchenko,
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| Collaboration | |||
| Country or International Organization | City | Institute or Laboratory | |
| Czech Republic | Prague | PTC | |
| ADVACAM | |||
| Rez | UJV | ||
| Moldova | Chisinau | MSU | |
| Poland | Otwock (Swierk) | NCBJ | |
| Poznan | GPCC | ||
| Romania | Bucharest | IFIN-HH | |
| Russia | Moscow | IBMP RAS | |
| DMS RAS | |||
| VIGG RAS | |||
| FMBC | |||
| Dubna | RDH-9 | ||
| Rostov-on-Don | SFedU | ||
| South Africa | Faure | iThemba LABS |
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