THEME08-9-1015-96/2003

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08-9-1015-96/2003

Priority:

Status:

In-progress

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment

Leader:

E. Krasavin
V. Aleinikov

Scientific Programme:
Radiation risk assessment is a crucial problem in occupational and public protection. It is well known that there is a lack of data needed to estimate risk of radiation stochastic effects (mutations and cancer diseases). Therefore, there is a need for obtaining new fundamental data on the induction of radiation stochastic effects for radiation with different linear energy transfer (LET). Accelerators and reactors of the Joint Institute are an excellent tool for modern radiation and radiobiological researches and give a unique possibility to obtain such data. The ultimate goal is to obtain fundamental physical and biological data based on experimental researches at basic facilities of JINR and on theoretical modeling of ionizing radiation interaction with matter. Accelerators and radiochemistry facilities of JINR are able to produce different radionuclides for development of new radiopharmaceutical preparations as well. Research and development will include:
- LET and neutron spectrometry, radiation and biosensor monitoring;
- theoretical modeling of ionizing radiation interaction with matter including interactions with biological structures and shielding calculations;
- experimental data obtaining for verification of theoretical modeling of ionizing radiation interaction with matter;
- investigations of peculiarities and mechanisms of point and structural mutation induction in pro- and eukaryotic cells by radiation with different LET;
- the problem of low doses of radiation with different LET and cell recovery;
- genetic and radiation monitoring of environment nuclear installations with biosensors and radiation monitors;
- investigation of "methylene blue - ²¹¹At" complex therapy efficiency in melanoma cells.

As the results:
- methods for radiation and genetic monitoring at nuclear installations of JINR and in environments will be developed;
- fundamental data for radiation risk assessments will be obtained;
- methods for targeted radiotherapy and diagnostics of melonoma will be developed.

Expected main results in 2002:

Main characteristics of the radiation fields at the JINR basic facilities and in the environment.
Calculations of nuclear facilities radiation shields.
Data about the regularities of induction of translocations in human lymphocytes after irradiation of ionizing radiation with different LET.
Data about the regularities of chromosomal aberrations in mammalian cells after gamma-irradiation with low doses.
Data about the regularities and mechanisms of mutagenic action of radiation with different LET on microorganisms.
The project "MITRA" - data about the distributions of ¹³¹I-MTB and ²¹¹At-MTB complexes in organisms of experimental animals with graft melanoma.
Measurements of the dosimetric characteristics of the particle beams used in the radiobiological experiments.

List of Activities

Activity or project

Spokespersons

Status

Radiation research

V. Aleinikov

Preparation
Data taking

Radiobiological research

E. Krasavin

Data taking
Realization

Project MITRA

E. Krasavin
N. Shmakova
V. Korsounski

Data taking

Training activity

V. Aleinikov
E. Krasavin
S. Ivanova

Collaboration
Country or international organization	City	Institute or Laboratory
Armenia	Yerevan	YerPhI
Belarus	Minsk	IRB NASB
Bulgaria	Sofia	INRNE BAS
CERN
Czech Republic	Brno	IBP ASCR
	Rhzehz	NPI ASCR
Germany	Cologne	DLR
Hungary	Debrecen	ATOMKI
JINR	Dubna	FLNR
		LIT
		LHE
		DLNP
		UC
Mongolia	Ulaanbaatar	NUM
Poland	Otwock	IAE
	Cracow	NINP
Russia	Moscow	RCRC RAS
		SRC-IBMP
	Puschino	ITEB RAS
	Gatchina	PNPI RAS
Slovak Republic	Bratislava	IPCM
Ukraine	Kiev	ICBGE NASU
	Sevastopol	IBSS NASU
USA	Houston	NASA

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Radiation and Radiobiological Investigations at the JINR Basic Facilities and in the Environment

Leader:

Radiation and Radiobiological Investigations
at the JINR Basic Facilities and in the Environment