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Research on the Biological Effect of Heavy Charged Particles
with Different Energies

• Research on the effect of accelerated heavy ions of different energies on genetic structures.
  
  
• Research on the interaction between the main cataractogenic factors (ionizing radiation, ultraviolet radiation, and age) during lens opacity formation.
  
  
• Research on the effect of different doses of accelerated charged particles on the retina and central nervous system of experimental animals.
  
  
• Mathematical modeling of induced mutagenesis in bacterial and eukaryotic cells.
  
  
• Molecular dynamics modeling of spatial structures of complex protein aggregates participating in DNA repair in bacterial and higher eukaryotic cells.
  
  
• Working out radiation protection measures for new nuclear physics facilities, evaluation of their radiation environment, and development of radiation safety systems for them.
  

• Acquisition of new data on the regularities and mechanisms of the initiation of molecular disorders in the DNA structure; DNA damage repair; and radiation-induced apoptosis in human cells under radiations with different linear energy transfer (LET).
  
  
• Decoding of the mechanisms underlying cell hypersensitivity and hyperresistance to low doses of ionizing radiation.
  
  
• Acquisition of comparative data on the regularities of the induction of gene and structural mutations in mammalian and yeast cells by radiations with different LET.
  
  
• Drawing up recommendations on the threshold doses of heavy charged particles able to damage the eye lens and retina. Development of the preventive measures against cataract in persons occupationally exposed to irradiation with heavy charged particles.
  
  
• Research on the character of the heavy charged particle-induced damage of central nervous system (CNS) cells and regularities of their death. Identification of the heavy charged particle-induced functional disorders in the CNS.
  
  
• Molecular dynamics modeling of radiation-induced conformational changes in biological structures.
  
  
• Mathematical modeling of the mutagenic effect of ionizing radiations with different LET on bacterial and mammalian cells.
  
  
• Calculation of the radiation shielding of new nuclear physics facilities; evaluation of the radiation environment and development of radiation safety systems.
  
  
• Research on the regularities in hematopoietic system damage formation in small laboratory animals with different irradiation schemes.
  
  
• Evaluation of the radiation load on interplanetary mission crew members' organisms depending on the solar cycle phase and shielding thickness.
  
  
• Estimation of the galactic radiation dose received by cosmonauts in different flight scenarios for working out the criteria and grounds of the radiation safety standards for interplanetary flights.
  
  
• Acquisition of new data on the performances of nanotechnology-based thermoluminescent detectors.

• Continuation of research on the regularities of DNA damage induction and repair in human and mammalian cells in the presence of modifiers of DNA replication and repair synthesis.
  
  
• Continuation of research on the mechanisms of radiation-induced apoptosis and different ways of DNA damage repair under ionizing radiations of different qualities.
  
  
• Research on the regularities of the formation and repair of DNA double-strand breaks and clustered damage using the method of DNA foci.
  
  
• Acquisition of data on the regularities of gene and structural mutation induction in yeast cells by radiations of different linear energy transfer (LET).
  
  
• Acquisition of data on the regularities of the induction of structural damage in the HPRT gene in mutant subclones of mammalian cells by radiations of different LET.
  
  
• Continuation of research on the mechanisms of the action of low doses of radiation of different LET using modifiers of intracellular cytoprotector systems.
  
  
• Acquisition of data on the regularities in the functional disorders in the rodent retina induced by radiations of different qualities and mutagens.
  
  
• Evaluation of the biological effect of Bragg peak protons for the total irradiation of mice.
  
  
• Teoretical evaluation of the radiation load on interplanetary flight crew depending on the solar cycle phase and shielding thickness.
  
  
• Continuation of the development of methods of mathematical moderling of the heavy charged particle effect on the central nervous system and visual apparatus of mammals.
  
  
• Development of approaches to the formulation of a new concept of the risk associated with the effect of heavy charged particles of the space origin on living systems.
  
  
• Continuation of the development of models of the genetic control of the molecular mechanisms in bacterial and mammalian cells under ionizing radiations of different LET.
  
  
• Carrying out dosimetry physics experiments at the Nuclotron (VBLHEP) and U-400M cyclotron (FLNR).
  
  
• Molecular dynamics modeling of the structural and functional properties of DNA photolyase and P53 protein.
  
  
• Calculation of the NICA collider shielding using the GEANT4 code.
  
  

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