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Multimodal Platform for Raman and Nonlinear Optical Microscopy
and Microspectroscopy for Condensed Matter Studies
and Microspectroscopy for Condensed Matter Studies
| Leader: | G.M. Arzumanyan |
Participating Countries and International Organizations:
Armenia, Belarus, Germany, Latvia, Poland, Romania, Russia, France.
Scientific Programme:
Experimental studies of condensed matter by Raman, CARS (coherent antiStokes Raman spectroscopy), and SERS (surface-enhanced Raman spectroscopy) spectroscopy and microscopy. Research of structural and optical properties, surface morphology and other characteristics of condensed matter on the multimodal optical platform constructed on the basis of the confocal laser scanning microscope "CARS". Raman spectroscopy is a non-invasive, label-free technique which excites vibrations of molecular bonds. Since optical microscopy is highly valuable to biomedical research, special attention will be given to the spectral-structural studies of various biological samples using coherent and surface-enhanced Raman spectroscopy. Another research direction deals with a study of photo- and upconversion luminescence of optical matrices (glass, glass-ceramics, colloidal nanocrystals) activated by various rare-earth elements.}
Expected main results in 2017:
- High contrast nonlinear chemical mapping of biosamples with a signal-to-noise ratio not less than 30:1 in the CARS and SERS options.
- First test-experiments aimed at achieving ultrahigh sensitivity on a single molecule detection level using coherent SERS modality.
- Revealing of molecular compositions and/or conformation changes that can occur in tissues during carcinogenesis or other pathologies.
- Completion of studies on structural and optical properties of transparent matrices based on ZnO nanocrystals codoped with rare earth elements.
- Plasmonic photo- and upconversion luminescence enhancement (not less than one order of magnitude) in phosphors activated with rare earth elements.
- Further development of the multimodal optical platform: utilization of 785nm laser excitation wavelength to suppress the autofluorescence background from samples under study.
| List of projects: | |||
| Project | Leader |
Priority (period of realisation) |
|
| 1. | Multimodal platform for Raman and nonlinear optical microscopy and microspectroscopy for condensed matter studies |
N. Kucerka Deputy: V.I. Gordeliy |
1 (2015-2017) |
| List of Activities | |||||
| Activity or Experiment | Leaders | ||||
| Laboratory or other Division of JINR Responsible person | Main researchers | ||||
| 1. | Application of the method of CARS and SERS microscopy aimed at high-contrast chemical selective imaging of various compounds and significant enhancement of the Raman scattering signal from samples under investigation | G.M. Arzumanyan N. Kucerka |
| ||
| FLNP | V.I. Gordeliy, K.Z. Mamatkulov, N.V. Doroshkevich, K.Sh. Voskanyan | ||||
| 2. | Development of nanostructured plasmon-enhanced Raman spectroscopy and microscopy method | G.M. Arzumanyan |
| ||
| FLNP | K.Z. Mamatkulov, N.V. Doroshkevich, E.À. Kuznetsov | ||||
| 3. | Investigation of phospholipid conformations in model membranes with Raman spectroscopy | G.M. Arzumanyan N. Kucerka V.I. Gordeliy |
| ||
| FLNP | K. Mamatkulov, K.Sh. Voskanyan, N.V. Doroshkevich, K.O. Demeshenkova | ||||
| 4. | A complex study of structural and spectral properties of optically transparent glasses and nanoglassceramics activated with various rare earth elements (REE) | G.M. Arzumanyan |
| ||
| FLNP | E.A. Kuznetsov, N.V. Doroshkevich | ||||
| 5. | Upgrade of the software and development of the instrumental infrastructure of the optical platform to expand its capabilities and increase the measurement sensitivity. | G.M. Arzumanyan N. Kucerka |
| ||
| FLNP | K. Mamatkulov, I.A. Morkovnikov, M.L. Korobchenko | ||||
| Collaboration | |||
| Country or International Organization | City | Institute or Laboratory | |
| Armenia | Yerevan | Inst. Physiology NAS RA | |
| Belarus | Minsk | BSUIR | |
| SOL instruments | |||
| Institute of Physiology NASB | |||
| Germany | Julich | FZJ | |
| Latvia | Riga | ISSP UL | |
| Poland | Lublin | UMCS | |
| Russia | Moscow | GPI RAS | |
| Dolgoprudny | MIPT | ||
| St. Petersburg | NITIOM | ||
| Romania | Bucharest | IFIN-HH | |
| UPB | |||
| France | Grenoble | IBS | |
| Ukraine | Donetsk | DonNU |
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