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04-4-1111-2013/2017
Priority:1
Status: Approved for completion
in 2017

Multimodal Platform for Raman and Nonlinear Optical Microscopy
and Microspectroscopy for Condensed Matter Studies


Leader:     G.M. Arzumanyan

Participating Countries and International Organizations:
Armenia, Belarus, Germany, Latvia, Poland, Romania, Russia, France.

Scientific Programme:
Experimental studies of condensed matter by Raman, CARS (coherent antiStokes Raman spectroscopy), and SERS (surface-enhanced Raman spectroscopy) spectroscopy and microscopy. Research of structural and optical properties, surface morphology and other characteristics of condensed matter on the multimodal optical platform constructed on the basis of the confocal laser scanning microscope "CARS". Raman spectroscopy is a non-invasive, label-free technique which excites vibrations of molecular bonds. Since optical microscopy is highly valuable to biomedical research, special attention will be given to the spectral-structural studies of various biological samples using coherent and surface-enhanced Raman spectroscopy. Another research direction deals with a study of photo- and upconversion luminescence of optical matrices (glass, glass-ceramics, colloidal nanocrystals) activated by various rare-earth elements.}

Expected main results in 2017:
  • High contrast nonlinear chemical mapping of biosamples with a signal-to-noise ratio not less than 30:1 in the CARS and SERS options.

  • First test-experiments aimed at achieving ultrahigh sensitivity on a single molecule detection level using coherent SERS modality.

  • Revealing of molecular compositions and/or conformation changes that can occur in tissues during carcinogenesis or other pathologies.

  • Completion of studies on structural and optical properties of transparent matrices based on ZnO nanocrystals codoped with rare earth elements.

  • Plasmonic photo- and upconversion luminescence enhancement (not less than one order of magnitude) in phosphors activated with rare earth elements.

  • Further development of the multimodal optical platform: utilization of 785nm laser excitation wavelength to suppress the autofluorescence background from samples under study.

List of projects:
  Project Leader Priority
(period of realisation)
1. Multimodal platform for Raman
and nonlinear optical microscopy
and microspectroscopy for condensed
matter studies
N. Kucerka
Deputy:
V.I. Gordeliy
1   (2015-2017)

List of Activities
  Activity or Experiment Leaders
Status
  Laboratory or other
Division of JINR
Responsible person
Main researchers
1. Application of the method of
CARS and SERS microscopy
aimed at high-contrast chemical
selective imaging of various
compounds and significant
enhancement of the Raman
scattering signal from
samples under investigation
G.M. Arzumanyan
N. Kucerka
Realization
Data taking
  FLNP V.I. Gordeliy, K.Z. Mamatkulov, N.V. Doroshkevich, K.Sh. Voskanyan
2. Development of nanostructured
plasmon-enhanced Raman
spectroscopy and microscopy
method
G.M. Arzumanyan
Data taking
Simulation
  FLNP K.Z. Mamatkulov, N.V. Doroshkevich, E.. Kuznetsov
3. Investigation of phospholipid conformations in model
membranes with Raman
spectroscopy
G.M. Arzumanyan
N. Kucerka
V.I. Gordeliy
Data taking
  FLNP K. Mamatkulov, K.Sh. Voskanyan, N.V. Doroshkevich,
K.O. Demeshenkova
4. A complex study of structural and
spectral properties of optically
transparent glasses and
nanoglassceramics activated
with various rare earth
elements (REE)
G.M. Arzumanyan
Realization
  FLNP E.A. Kuznetsov, N.V. Doroshkevich
5. Upgrade of the software and
development of the instrumental
infrastructure of the optical
platform to expand its capabilities
and increase the measurement sensitivity.
G.M. Arzumanyan
N. Kucerka
Upgrade
  FLNP K. Mamatkulov, I.A. Morkovnikov, M.L. Korobchenko

Collaboration
Country or International
Organization
City Institute or Laboratory
Armenia Yerevan Inst. Physiology NAS RA
Belarus Minsk BSUIR
SOL instruments
Institute of Physiology NASB
Germany Julich FZJ
Latvia Riga ISSP UL
Poland Lublin UMCS
Russia Moscow GPI RAS
Dolgoprudny MIPT
St. Petersburg NITIOM
Romania Bucharest IFIN-HH
UPB
France Grenoble IBS
Ukraine Donetsk DonNU

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