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Modern Trends and Developments in Raman Microspectroscopy and Photoluminescence for Condensed Matter Studies
| Leaders: | G.M. Arzumanyan N. Kucerka |
Participating countries and international organizations:
Armenia, Belarus, Bulgaria, Egypt, Germany, Latvia, Poland, Russia, Slovakia, Ukraine.
Issues addressed and main goals of research:
Modern trends in Raman-based microspectroscopy providing ultrasensitive, highly-contrast and chemically selective tools for condensed matter studies of extremely low concentrations of analyte molecules are in the focus of the present research programme. Detection and identification of a single molecule represent the ultimate sensitivity limit in chemical analysis.
Tracking and counting of single molecules, characterizing their chemical structures offer far-reaching opportunities in basic and applied research. Therefore, vibrational spectroscopy, such as Raman spectroscopy, as a non-invasive, label-free technique, is a powerful and preferred tool for rareorganic/biological molecule studies. To achieve this goal, two enhanced options of Raman scattering, namely CARS (coherent antiStokes Raman spectroscopy) and SERS (surface-enhanced Raman spectroscopy) will be combined to attain such an ultrasensitive level of detectior poorly studied and known as SECARS surface-enhanced CARS.
The other modern component of the theme is the study of photo- and upconversion luminescence based on promising core-shell nanostructures. In recent years, core-shell nanoparticles are at the leading edge of hot research topics and offer a wide range of applications in biomedicine, optics, environmental science, materials, and so forth, due to their excellent properties such as versatility, tunability and stability. The core-shell nanomaterials containing noble metals are plasmonic nanomaterials. They can be employed for contrast imaging, several biomedical applications, etc.
Expected major results in the current year:
- Development of the wavelength scanning mode for picosecond coherent anti-Stokes Raman microspectrometry.
- Continuation of the tests of various configurations of SERS-active substrates to ensure optimal selection for the effective SECARS spectroscopy.
- Comparison of SERS and SECARS spectra and intensity maps of light scattered from organic reporter molecules.
- Synthesis of core-shell nanostructure: NaYF4:Yb 3+, Er 3+,Tm 3+@SiO2 and tests on their toxicity.
- Realization of a contrast and selective imaging method on model samples by Raman and upconversion luminescence.
| List of projects: | |||
| Project | Leader |
Priority (period of realisation) |
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| 1. | NANOBIOPHOTONICS | G.M. Arzumanyan N. Kucerka Deputy: K.Z. Mamatkulov |
1 (2018-2020) |
| List of Activities | |||||
| Activity or Experiment | Leaders | ||||
| Laboratory or other Division of JINR | Main researchers | ||||
| 1. | Development of scientific and technical requirements to upgrade the "CARS" microspectrometer for ultrasensitive SECARS modality | G.M. Arzumanyan |
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| FLNP | N.V. Doroshkevich, K.Z. Mamatkulov, I.A. Morkovnikov | ||||
| 2. | Study of spectroscopic and plasmonic characteristics of SERS-active substrates based on silver/gold nanoparticles with different configurations | G.M. Arzumanyan N. Kucerka |
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| FLNP | N.V. Doroshkevich, A.S. Marchenko, K.Z. Mamatkulov, N.V. Doroshkevich, M.Ju. Vorobjeva | ||||
| 3. | Systematic experiments on SECARS microspectroscopy with picosecond laser pulses at SERS-active substrates single molecule spectroscopy | G.M. Arzumanyan K.Z. Mamatkulov |
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| FLNP | N.V. Doroshkevich, I.A. Morkovnikov, K.Sh. Voskanyan, M.Ju. Vorobjeva | ||||
| 4. | Development of plasmon-enhanced model of Raman scattering on the "CARS" microscope | G.M. Arzumanyan N. Kucerka |
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| FLNP | K.Z. Mamatkulov, I.A. Morkovnikov | ||||
| 5. | Study of spectral-structural characteristics of upconversion phosphors based on core-shell type nanostructures | G.M. Arzumanyan N. Kucerka |
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| FLNP | N.V. Doroshkevich, K.Z. Mamatkulov, A.S. Marchenko, M.Ju. Vorobjeva, K.Sh. Voskanyan, M.Ju. Vorobjeva | ||||
| 6. | Test-application of core-shell nanostructured phosphors in photodynamic therapy (PDT) of cancer | G.M. Arzumanyan N. Kucerka |
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| FLNP | N.V. Doroshkevich, A.S. Marchenko, K.Z. Mamatkulov, M.Ju. Vorobjeva, K.Sh. Voskanyan | ||||
| 7. | Development of a united optical platform concept for contrast and selective imaging by nonlinear Raman microscopy and upconversion luminescence. | G.M. Arzumanyan |
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| FLNP | K.Z. Mamatkulov, A.S. Marchenko | ||||
| 8. | Broadening the scope of research activities at the "CARS" microscope as a "user-friendly facility" | G.M. Arzumanyan N. Kucerka |
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| FLNP | N.V. Doroshkevich, K.Z. Mamatkulov | ||||
| Collaboration | |||
| Country or International Organization | City | Institute or Laboratory | |
| Armenia | Yerevan | Inst. Biochemistry NAS RA | |
| Belarus | Minsk | BSUIR | |
| SOL instruments | |||
| Bulgaria | Sofia | Inst. Microbiology BAS | |
| Egypt | Giza | CU | |
| Germany | Julich | FZJ | |
| Latvia | Riga | ISSP UL | |
| Poland | Wroclaw | UW | |
| Poznan | AMU | ||
| Russia | Moscow | GPI RAS | |
| MSU | |||
| Slovakia | Kosice | PJSU | |
| Ukraine | Donetsk | DonNU |
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