THEME04-2-1132-2017/2022

Biomedical and clinical research of proton radiotherapy for cancer treatment. Formation of an experimental data base in the field of radiation mutagenesis in the animal germ cells.

Expected results in the current year:

Evaluation of effectiveness of conducted radiation treatment of different neoplasms.
Increase of functional capability of the developed 3D treatment planning software.
Design and construction of prototype equipment for dynamic conformal irradiation of deep-seated tumours with the proton beam.
Development and improvement of detectors and tools for clinical dosimetry of medical hadron beams.
Continuation of research to determine forms of fibroblast cell death depending on the dose of ionizing radiation.
Study of mechanisms of functional and neurochemical disorders in the central nervous system during exposure to radiation with different linear energy transfer.
Mastering of new methods for evaluation of effectiveness of cytotoxic activity of nanoparticles on tumour cells.
Continuation of the molecular analysis of gamma- and neutron-induced intragenic structural changes in germline cells.
Continuation of the sequence analysis of inherited DAN changes at the genome level of the offspring.
Continuation of the work on the analysis of the transcriptome in somatic cells differing in radiosensitivity.
Assessment of radioresistance of D.melanogaster strains and the human cell line HEK293 expressing DSUP protein (gamma rays, protons, heavy ions).
Transcriptome analysis of D.melanogaster strains and the human cell line HEK293 expressing Dsup protein.
Study of distribution of GEP-Dsup fusion protein on D.melanogater polytene chromosomes.
Development of a project of a specialized isochronous cyclotron for proton therapy.
Measurements of the magnetic field of the MC1 bending magnet for the transport line of the AIC-144, Krakow, Poland.

List of projects:
	Project	Leader	Priority (period of realisation)
1.	Further development of methods, technologies, schedule modes and provision of radiotherapy	G.V. Mitsyn	1 (2017-2022)
2.	RADIOGENE: Molecular genetics of radiation-induced changes at the gene, genome and transcriptome level in Drosophila melanogaster	I.D. Alexandrov	1 (2017-2022)

Study of the radioprotective
properties of the Damage supressor (Dsup)
protein on a model organism D.melanogaster
and the human cell culture HEK293

E.V. Kravchenko

1 (2021-2022)

List of Activities:

Activity or Experiment

Leaders

Status

Laboratory or other
Division of JINR

Main researchers

Further development of methods,
technologies, schedule modes and
provision of radiotherapy

G.V. Mitsyn

Realization

DLNP

A.V. Agapov, I.V. Alexandrova, O.V. Belov, K. Belokopytova,
G.V. Donskaya, V.N. Gaevsky, I.I. Klochkov, I. Khosenova,
Ye.I. Luchin, I.Ye. Miller, A.G. Molokanov, S.A. Pisareva,
A.V. Rzyanina, K.N. Shipulin, S.V. Shvidky

RADIOGENE: Molecular genetics
of radiation-induced changes at the
gene, genome and transcriptome
level in Drosophila melanogaster

I.D. Alexandrov

Realization

DLNP

M.V. Alexandrova, K.P. Afanasyeva, N.E. Kharchenko,
S.V. Korablinova, L.N. Korovina, N.V. Orlova, A.N. Rusakovich, O.P. Solodilova

Study of the radioprotective properties
of the Damage supressor (Dsup) protein
on a model organism D.melanogaster
and the human cell culture HEK293

E.V. Kravchenko

Realization

DLNP

A.E. Ivanova, O.A. Kuldoshina, A.V. Rzyanina, A.S. Yakunenko, M.P. Zarubin

Development of methods and programs
for creating cyclotron-type accelerators. Development and upgrade of cyclotrons
for medical application

G.A. Karamysheva

Realization

DLNP

K.S. Bunyatov, A.F. Chesnov, S.N. Dolya, S.B. Fedorenko,
R.V. Galkin, A.L. Gibinsky, S.V. Gursky, G.G. Kazakova,
O.V. Karamyshev, I.N. Kiyan, O.E. Lepkina,
O.V. Lomakina, I.V. Lyapin, V.A. Malinin, D.S. Petrov,
D.V. Popov, G.D. Shirkov, S.G. Shirkov, V.L. Smirnov,
A.S. Vorozhtsov, S.B. Vorozhtsov

MLIT

I.V. Amirhanov, T.V. Karamysheva

Collaboration

Country or International Organization	City	Institute or laboratory
Belgium	Louvain-la-Neuve	IBA
China	Hefei	IPP CAS
Czech Republic	Prague	ADVACAM
		PTC
	Rez	UJV
Moldova	Chisinau	MSU
Poland	Krakow	INP PAS
	Otwock (Swierk)	NCBJ
	Poznan	GPCC
Romania	Bucharest	IFIN-HH
Russia	Dubna	RDH-9
	Moscow	DMS RAS
		FMBC
		IBMP RAS
		VIGG RAS
	Rostov-on-Don	SFedU
South Africa	Somerset West	iThemba LABS
USA	Lansing, MI	IONETIX
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Biomedical and Radiation-Genetic Studies Using Different Types of Ionizing Radiation

Biomedical and Radiation-Genetic Studies Using Different Types
of Ionizing Radiation