Modern
Trends and Developments in Raman Microspectroscopy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Leaders: |
G.M. Arzumanyan |
Participating
countries and international organizations:
Armenia, Belarus, Bulgaria, Poland, Romania, Russia, Serbia, Slovakia, Uzbekistan.
Issues
addressed and main goals of research:
Fundamental and applied research in the field of spontaneous and nonlinear Raman microspectroscopy aimed at highly sensitive biosensing. Study of mechanisms and nature of surface-enhanced Raman scattering (SERS) taking into account the anomalous ratio of line inteities in the anti-Stokes and Stokes spectral regions. Applied research is aimed at the use of Raman spectroscopy and fluorescence microscopy in biomedical research, in particular, in the search for spectral markers of NETosis, as well as some features of lipid-protein interactions.
Expected results in the current year:
Detection of Raman spectra of organic molecules in the low-frequency region using Bragg filters simultaneously in the Stokes and anti-Stokes regions.
Investigation of a possible anomaly in the ratio of the peaks aSt / St in the SERS spectra depending on the continuous and pulsed pumping modes.
Synthesis of liposomes / liposomes with embedded proteins and the study of their chemical structure and morphology by Raman spectroscopy and fluorescence microscopy.
UV-induced NETOSIS: identification of dependence on wavelength and intensity of irradiation.
Application of fluorescence microscopy to identify programmed death of neutrophil cells under the influence of various activators, including UV radiation.
List of projects: |
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Project |
Leaders |
Priority |
|
1. |
BIOPHOTONICS |
G.M.
Arzumanyan |
1 (2021-2023) |
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|
Activity or Experiment |
Leaders |
Status |
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Laboratory
or other |
Main researchers |
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1. |
Study
of the features of Stokes and |
G.M. Arzumanyan |
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|
FLNP |
Ye.
Arynbek, K.Z. Mamatkulov, I.A. Morkovnikov, 2 engineers
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2. |
Determination
of the range of pump |
G.M.
Arzumanyan |
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|
FLNP |
Ye.
Arynbek, M.Yu. Vorobyeva, 1 engineer |
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3. |
Stabilization
of membrane proteins |
G.M.
Arzumanyan |
|
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|
FLNP |
A.
Damir, K.Z. Mamatkulov, M.Yu. Vorobyeva |
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4. |
Testing
the technique for obtaining |
K.Z.
Mamatkulov |
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FLNP |
Ye.
Arynbek, A. Damir, M.Yu. Vorobyeva, 1 engineer |
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5. |
Study
of the influence of lipid |
G.M.
Arzumanyan |
|
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|
FLNP |
K.Z.
Mamatkulov, M.Yu. Vorobyeva, 1 engineer, 2 laboratory
assistants |
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6. |
Search
for spectral / Raman markers |
G.M.
Arzumanyan |
|
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|
FLNP |
K.Z.
Mamatkulov, M.Yu. Vorobyeva, 1 engineer, 2 laboratory assistants |
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7. |
Study
of mechanisms of sterile activation |
G.M.
Arzumanyan |
|
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|
FLNP |
A. Damir,
M.Yu. Vorobyeva, D.S. Zakritnaya |
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8. |
Mastering
the technique of ultra-low |
G.M.
Arzumanyan |
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|
FLNP |
Ye. Arynbek, M.Yu. Vorobyeva, 2 engineers |
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Collaboration
Country or International Organization |
City |
Institute or laboratory |
Armenia |
Yerevan |
Foundation ANSL |
Belarus |
Minsk |
BSUIR |
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SOL instruments |
Bulgaria |
Sofia |
ISSP BAS |
Poland |
Krakow |
JU |
Romania |
Brasov |
UNITBV |
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Bucharest |
CSSNT-UPB |
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Cluj-Napoca |
INCDTIM |
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Magurele |
NIMP |
Russia |
Moscow |
GPI RAS |
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LMPR MONIKI |
Serbia |
Belgrade |
Univ. |
Slovakia |
Kosice |
UPJS |
Uzbekistan |
Jizzakh |
JSPI |
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